E-mail: Tang_Chun@pku.edu.cn

Website: http://www.tanglab.org

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Prof. Weiping Zhang(张纬萍)

Tel: 0571-88208223
E-Mail: weiping601@zju.edu.cn

Main Research

博士生导师，浙江大学基础医学院副教授。长期关注脑衰老和神经退行性疾病机制及防治的研究。通过研究蛋白质、蛋白质机器的动态结构和动态相互作用，揭示NAMPT及相关药物延缓衰老、减轻神经退行性改变的作用；阐明了PINK1-pUb调控蛋白酶体降解蛋白质，在蛋白质稳态失衡中的作用，蛋白质稳态失衡对脑衰老及神经退行性疾病的影响。研究获得多项国家自然科学基金、科技部蛋白质重大项目的资助，研究成果在Aging Cell（2023）、Molecular Neurobiology（2022）、JCBFM（2021,2010）、JMB（2020）、Cell Discovery （2019）、J of Neurochemistry（2019）、PNAS（2017）、Cell（2004）等发表。

Prof. Huali Wang(王华丽)

博士生导师，教授，任北京大学第六医院临床研究室主任，记忆障碍诊疗与研究中心执行主任，及痴呆诊治转化医学研究北京市重点实验室副主任。主要研究方向为老年情绪与认知障碍的早期诊断与干预技术。先后承担痴呆相关的国家科技创新2030 –– “脑科学与类脑研究”重大项目课题、科技部慢病重点研发项目、首都临床特色诊疗技术研究及转化应用重点项目等50余项。作为第一作者或通讯作者发表中英文学术论文百余篇。目前担任International Psychogeriatrics副主编、中国老年学和老年医学学会精神卫生分会主任委员、中国老年医学学会精神医学与心理健康分会副会长、中国老年保健协会阿尔茨海默病分会常务副主任委员、国际阿尔茨海默病协会常务理事等职务。

Publications

85 Xue-Ni Hou, Bin Song, Chang Zhao, Wen-Ting Chu, Mei-Xia Ruan, Xu Dong, Ling-Shen Meng, Zhou Gong, Yu-Xiang Weng, Jie Zheng*, Jin Wang*, Chun Tang*, (2024), “Connecting Protein Millisecond Conformational Dynamics to Protein Thermal Stability” JACS Au. https://doi.org/10.1021/jacsau.4c00649.

84 Yida Jiang, Xinghe Zhang, Honggang Nie, Jianxiong Fan, Shuangshuang Di, Hui Fu, Xiu Zhang, Lijuan Wang, Chun Tang, (2024), “Dissecting diazirine photo-reaction mechanism for protein residue-specific cross-linking and distance mapping” Nat Commun 15(1), 6060 . https://doi.org/10.1038/s41467-024-50315-y.

83 Mateusz Leśniewski, Maciej Pyrka, Cezary Czaplewski, Nguyen Truong Co, Yida Jiang, Zhou Gong, Chun Tang, Adam Liwo, (2024), “Assessment of Two Restraint Potentials for Coarse-Grained Chemical-Cross-Link-Assisted Modeling of Protein Structures” J. Chem. Inf. Model. 64, 4, 1377–1393. https://doi.org/10.1021/acs.jcim.3c01890.

82 Sze Yuet Chin, Yunpeng Lu, Weishuai Di, Kai Ye, Zihan Li, Chenlu He, Yi Cao, Chun Tang, and Kai Xue, (2023), “Regulating polystyrene glass transition temperature by varying the hydration levels of aromatic ring/Li+ interaction” Phys. Chem. Chem. Phys. https://pubs.rsc.org/en/Content/ArticleLanding/2023/CP/D3CP02995F

81 Xuhui Yan, Feiqing Liu, Junjun Yan, Mengjun Hou, Min Sun, Delin Zhang, Zhou Gong, Xu Dong, Chun Tang, and Ping Yin, (2023), “WTAP–VIRMA counteracts dsDNA binding of the m6A writer METTL3–METTL14 complex and maintains N6-adenosine methylation activity” Cell Discovery 9. https://www.nature.com/articles/s41421-023-00604-5

80 Weishuai Di, Kai Xue, Jun Cai, Zhenshu Zhu, Zihan Li, Hui Fu, Hai Lei, Wenbing Hu, Chun Tang, Wei Wang, and Yi Cao, (2023), “Single-Molecule Force Spectroscopy Reveals Cation-π Interactions in Aqueous Media Are Highly Affected by Cation Dehydration” Phys. Rev. Lett. 130, 118101. https://doi.org/10.1103/PhysRevLett.130.118101

79 Weitao Fu, Hao Yang, Chenxian Hu, Jianing Liao, Zhou Gong, Minkui Zhang, Shuai Yang, Shangxiang Ye, Yixuan Lei, Rong Sheng, Zhiguo Zhang, Xiaojun Yao, Chun Tang*, Dan Li*, and Tingjun Hou*, (2023), “Small-Molecule Inhibition of Androgen Receptor Dimerization as a Strategy against Prostate Cancer” ACS Cent. Sci. https://doi.org/10.1021/acscentsci.2c01548

78 Wang Jian-Hua, Gong Zhou, Dong Xu, Liu Shu-Qun, Tang Yu-Liang, Lei Xiaoguang, Tang Chun, Dong Meng-Qiu, (2022), “Fast cross-linking by DOPA2 promotes the capturing of a stereospecific protein complex over nonspecific encounter complexes”. Biophysics Reports. https://doi.org/10.52601/bpr.2022.220014

77 Xuhui Yan, Kai Pei, Zeyuan Guan, Feiqing Liu, Junjun Yan, Xiaohuan Jin, Qiang Wang, Mengjun Hou, Chun Tang & Ping Yin, (2022) “AI-empowered integrative structural charac terization of m⁶A methyltransferase complex” Cell Research .https://doi.org/10.1038/s41422-022-00741-8

76 Jian-Hua Wang, Yu-Liang Tang, Zhou Gong, Rohit Jain, Fan Xiao, Yu Zhou, Dan Tan, Qiang Li, Niu Huang, Shu-Qun Liu, Keqiong Ye, Chun Tang, Meng-Qiu Dong, and Xiaoguang Lei, (2022),”Characterization of protein unfolding by fast cross-linking mass spectrometry using di-ortho-phthalaldehyde cross-linkers” Nat Commun 13, 1468. https://doi.org/10.1038/s41467-022-28879-4

75 Yingxue Ma, Haozheng Li, Zhou Gong, Shuai Yang, Ping Wang, and Chun Tang, (2022),”Nucleobase Clustering Contributes to the Formation and Hollowing of Repeat-Expansion RNA Condensate” J. Am. Chem. Soc. https://doi.org/10.1021/jacs.1c12085

74 Xu Dong, Ling-Yun Qin, Zhou Gong, Sanbo Qin, Huan-Xiang Zhou, and Chun Tang, (2022).”Preferential Interactions of a Crowder Protein with the Specific Binding Site of a Native Protein Complex” J. Phys. Chem. Lett.: 792–800.https://doi.org/10.1021/acs.jpclett.1c03794

73 Czaplewski, C., et al. (2021). “Recent Developments in Data-Assisted Modeling of Flexible Proteins.” Frontiers in Molecular Biosciences 8(1306).https://doi.org/10.3389/fmolb.2021.765562

72 Fu, W., et al. (2021). “Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers.” Journal of Medicinal Chemistry 64(23): 17221-17238.https://doi.org/10.1021/acs.jmedchem.1c01287

71 Kogut M, Gong Z, Tang C, Liwo A. (2021) Pseudopotentials for coarse‐grained cross‐link‐assisted modeling of protein structures
M Kogut, Z Gong, C Tang, A Liwo Journal of Computational Chemistry 42 (29), 2054-2067 Journal of Computational Chemistry, doi.org/10.1002/jcc.26736

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4月12日，春风和煦，阳光明媚，山间的薄霾并未阻挡春游的脚步，Tanglab成员沿香八拉徒步路线，开展了一次强健体魄，增进情谊的团建活动。
初行两三里，便逢懒汉坡。像是并不认同这自嘲般的“对号入座”，用绝佳的角度将这一刻定格在“懒又皮”

山上仍有些料峭，春色虽未遍及山野，大家爬山却依旧兴致热烈。山间邂逅一只大橘，慵懒惬意，为旅途增添几分山林野趣。

又逢好汉坡，来张大合影！

下山已是午后，大家在国家植物园内游览，花开的热烈，园子里一片生机盎然的景象，弥补了香山未见春色的遗憾。

最后，大家乘坐西郊线回到学校，以一顿丰盛的烤肉为此次香山之旅画上圆满句号。感谢唐老师的款待！

Yunli Zhao(赵云丽)

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Xueni Hou

Email: hou.xueni.44x@pku.edu.cn

Hi, I am Xue-Ni Hou, received my MSc from China Agriculture University in 2016, then joined the group of Prof. Hidehito Tochio and received my Ph.D. from Kyoto University (Japan) in Sept 2021. Happy to join Tang Lab from Dec 2021. I am now continuing my research on the conformational states of biomacromolecules.

Liyuan Wang

I am Wang Liyuan, a Gemini girl who loves taking photos, citywalk, and playing table tennis. I recived Ph.D. from Yanbian University in the group of Prof.Li Donghao. It’s honored to join the Tang Lab and start my postdoctoral research on chemical cross-linking mass spectrometry.

本文面向Tanglab及其它小型团队的工作人员

本系列教程旨在简化教学流程，并提供小型团队飞书GPT-BOT搭建的思路。

本系列教程所需的预备知识（prerequisite）包括服务器的运维和chatGPT的使用

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本文面向Tanglab及其它小型团队的工作人员

本文在一定程度上参考了MDN Web Docs，本系列教程旨在简化教学流程，并提供小型团队数据库搭建的思路。若希望更为全面地掌握Django及其它数据库知识，应阅读官方文档。

本系列教程所需的预备知识（prerequisite）仅包括浏览器使用和基本数据逻辑

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9月26日，在秋风习习，凉爽舒适的天气中，Tanglab成员在天津开展了团建活动。

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Meng Ling-shen (孟令屾)

E-mail: 1600011738@pku.edu.cn

My name is Meng Ling-shen, a student from PKU CCME. It’s my pleasure to be a member of Tang lab.

Xuzheng Wang(王旭正)

E-mail: 623858043@stu.pku.edu.cn

I’m Xuzheng Wang. Graduated from Xiamen University, I joined Tanglab in 2020. Now I am studying in College of Chemistry and Molecular Engineering, Peking University. It’s a great honor to meet everyone in Tanglab.

Zihan Li(李梓焓)

E-mail: chemlzh@pku.edu.cn

Hello, I’m Zihan Li, an undergraduate student from Peking University, and now a member of Tang’s Lab. I’m pleased to work together with senior schoolmates in Tang’s Lab, and I’m ready to do more researches in solution NMR and protein dynamic structures.

Xinyuan Lu(卢信源)

E-mail:2101110403@pku.edu.cn

Hello, my name is Xinyuan Lu, and I graduated from PKU CCME with a bachelor’s degree in 2021. I’m honored to have been accepted into Tang Lab to pursue a Ph.D. My present research focuses on the development of probes for solvent paramagnetic relaxation enhancement (sPRE).

Kai Pei（裴凯）

E-mail:2106596201@pku.edu.cn

I am Kai Pei. I graduated from Hua Zhong Agriculture University. I am major in Biochemistry and Molecular Biology. Now I work in Tang Lab as a research assistant.

Yida Jiang(江意达)

Hi, I’m Yida Jiang, graduated in PKU CCME, and continue my Ph.D. degree in Tang Lab. My recent work will be posted on jiangyida.top.

• Name：Yida Jiang
• E-Mail: jiangyida@pku.edu.cn
• Wechat: jiang_yida
• QQ: 476540183
• Github: https://github.com/DF-Master

Xinghe Zhang(张兴赫)

E-mail:chemxhzhang@stu.pku.edu.cn

My name’s Zhang Xinghe. Majored in chemistry, I obtained my bachelor’s degree in Wuhan University. In the next five, or at least five years, I wish to make some ferocious activity (zhěng diǎn hěn huó) in the field of biological physics, protein characterization especially.

Yuhao Li(李煜昊)

I’m Yuhao Li . I obtained my Bachelor’s degree from Peking University at 2022. And now I am continuing my career in PKU CCME and studying from my PhD in Tang lab. It’s a great pleasure to do my research in such a passionate and fun team.

Yuanzheng lei(雷原正)

E-mail: 2201111974@stu.pku.edu.cn
Hi, I’m Lei Yuanzheng. I graduated from school of physics, PKU with a bachelor’s degree. Now I’m studying for my Ph.D. degree in Tang Lab. I’m now working on characterization of protein phase separation.

Jianxiong fan(范健雄)

E-mail: jxfan@stu.pku.edu.cn
Hi, I’m Fan Jianxiong. Majored in applied chemistry, I graduated from East China University of Science and Technology in 2023. It’s my honor to be a member of Tang Lab.

Runtao Zhao(赵润涛)

E-Mail: zrt2002@pku.edu.cn
WeChat: mauphu
Github: https://github.com/zrt2002
Hi, I am Zhao Runtao, graduated from Peking University and currently working on my PhD at Tanglab.