Publications

82 Sze Yuet Chin, Yunpeng Lu, Weishuai Di, Kai Ye, Zihan Li, Chenlu He, Yi Cao, Chun Tang, and Kai Xue, (2023), “Regulating polystyrene glass transition temperature by varying the hydration levels of aromatic ring/Li+ interaction” Phys. Chem. Chem. Phys. https://pubs.rsc.org/en/Content/ArticleLanding/2023/CP/D3CP02995F

81 Xuhui Yan, Feiqing Liu, Junjun Yan, Mengjun Hou, Min Sun, Delin Zhang, Zhou Gong, Xu Dong, Chun Tang, and Ping Yin, (2023), “WTAP–VIRMA counteracts dsDNA binding of the m6A writer METTL3–METTL14 complex and maintains N6-adenosine methylation activity” Cell Discovery 9, https://www.nature.com/articles/s41421-023-00604-5

80 Weishuai Di, Kai Xue, Jun Cai, Zhenshu Zhu, Zihan Li, Hui Fu, Hai Lei, Wenbing Hu, Chun Tang, Wei Wang, and Yi Cao, (2023), “Single-Molecule Force Spectroscopy Reveals Cation-π Interactions in Aqueous Media Are Highly Affected by Cation Dehydration” Phys. Rev. Lett. 130, 118101 https://doi.org/10.1103/PhysRevLett.130.118101

79 Weitao Fu, Hao Yang, Chenxian Hu, Jianing Liao, Zhou Gong, Minkui Zhang, Shuai Yang, Shangxiang Ye, Yixuan Lei, Rong Sheng, Zhiguo Zhang, Xiaojun Yao, Chun Tang*, Dan Li*, and Tingjun Hou*, (2023), “Small-Molecule Inhibition of Androgen Receptor Dimerization as a Strategy against Prostate Cancer” ACS Cent. Sci. https://doi.org/10.1021/acscentsci.2c01548

78 Wang Jian-Hua, Gong Zhou, Dong Xu, Liu Shu-Qun, Tang Yu-Liang, Lei Xiaoguang, Tang Chun, Dong Meng-Qiu, (2022), “Fast cross-linking by DOPA2 promotes the capturing of a stereospecific protein complex over nonspecific encounter complexes”. Biophysics Reports. https://doi.org/10.52601/bpr.2022.220014

77 Xuhui Yan, Kai Pei, Zeyuan Guan, Feiqing Liu, Junjun Yan, Xiaohuan Jin, Qiang Wang, Mengjun Hou, Chun Tang & Ping Yin, (2022) “AI-empowered integrative structural charac terization of m⁶A methyltransferase complex” Cell Research https://doi.org/10.1038/s41422-022-00741-8

76 Jian-Hua Wang, Yu-Liang Tang, Zhou Gong, Rohit Jain, Fan Xiao, Yu Zhou, Dan Tan, Qiang Li, Niu Huang, Shu-Qun Liu, Keqiong Ye, Chun Tang, Meng-Qiu Dong, and Xiaoguang Lei, (2022),”Characterization of protein unfolding by fast cross-linking mass spectrometry using di-ortho-phthalaldehyde cross-linkers” Nat Commun 13, 1468. https://doi.org/10.1038/s41467-022-28879-4

75 Yingxue Ma, Haozheng Li, Zhou Gong, Shuai Yang, Ping Wang, and Chun Tang, (2022),”Nucleobase Clustering Contributes to the Formation and Hollowing of Repeat-Expansion RNA Condensate” J. Am. Chem. Soc. https://doi.org/10.1021/jacs.1c12085

74 Xu Dong, Ling-Yun Qin, Zhou Gong, Sanbo Qin, Huan-Xiang Zhou, and Chun Tang, (2022).”Preferential Interactions of a Crowder Protein with the Specific Binding Site of a Native Protein Complex” J. Phys. Chem. Lett.: 792–800https://doi.org/10.1021/acs.jpclett.1c03794

73 Czaplewski, C., et al. (2021). “Recent Developments in Data-Assisted Modeling of Flexible Proteins.” Frontiers in Molecular Biosciences 8(1306).https://doi.org/10.3389/fmolb.2021.765562

72 Fu, W., et al. (2021). “Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers.” Journal of Medicinal Chemistry 64(23): 17221-17238.https://doi.org/10.1021/acs.jmedchem.1c01287

71 Kogut M, Gong Z, Tang C, Liwo A. (2021) Pseudopotentials for coarse‐grained cross‐link‐assisted modeling of protein structures
M Kogut, Z Gong, C Tang, A Liwo Journal of Computational Chemistry 42 (29), 2054-2067 Journal of Computational Chemistry, doi.org/10.1002/jcc.26736

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Meng Ling-shen (孟令屾)

E-mail: 1600011738@pku.edu.cn

My name is Meng Ling-shen, a student from PKU CCME. It’s my pleasure to be a member of Tang lab.

Xuzheng Wang(王旭正)

E-mail: 623858043@stu.pku.edu.cn

I’m Xuzheng Wang. Graduated from Xiamen University, I joined Tanglab in 2020. Now I am studying in College of Chemistry and Molecular Engineering, Peking University. It’s a great honor to meet everyone in Tanglab.

Zihan Li(李梓焓)

E-mail: chemlzh@pku.edu.cn

Hello, I’m Zihan Li, an undergraduate student from Peking University, and now a member of Tang’s Lab. I’m pleased to work together with senior schoolmates in Tang’s Lab, and I’m ready to do more researches in solution NMR and protein dynamic structures.

Xinyuan Lu(卢信源)

E-mail:2101110403@pku.edu.cn

Hello, my name is Xinyuan Lu, and I graduated from PKU CCME with a bachelor’s degree in 2021. I’m honored to have been accepted into Tang Lab to pursue a Ph.D. My present research focuses on the development of probes for solvent paramagnetic relaxation enhancement (sPRE).

Kai Pei（裴凯）

E-mail:2106596201@pku.edu.cn

I am Kai Pei. I graduated from Hua Zhong Agriculture University. I am major in Biochemistry and Molecular Biology. Now I work in Tang Lab as a research assistant.

Yida Jiang(江意达)

Hi, I’m Yida Jiang, graduated in PKU CCME, and continue my Ph.D. degree in Tang Lab. My recent work will be posted on jiangyida.top.

• Name：Yida Jiang
• E-Mail: jiangyida@pku.edu.cn
• Wechat: jiang_yida
• QQ: 476540183
• Github: https://github.com/DF-Master

Xinghe Zhang(张兴赫)

E-mail:chemxhzhang@stu.pku.edu.cn

My name’s Zhang Xinghe. Majored in chemistry, I obtained my bachelor’s degree in Wuhan University. In the next five, or at least five years, I wish to make some ferocious activity (zhěng diǎn hěn huó) in the field of biological physics, protein characterization especially.

Yuhao Li(李煜昊)

I’m Yuhao Li . I obtained my Bachelor’s degree from Peking University at 2022. And now I am continuing my career in PKU CCME and studying from my PhD in Tang lab. It’s a great pleasure to do my research in such a passionate and fun team.

Yuanzheng lei(雷原正)

E-mail: 2201111974@stu.pku.edu.cn
Hi, I’m Lei Yuanzheng. I graduated from school of physics, PKU with a bachelor’s degree. Now I’m studying for my Ph.D. degree in Tang Lab. I’m now working on characterization of protein phase separation.

Jianxiong fan(范健雄)

E-mail: jxfan@stu.pku.edu.cn
Hi, I’m Fan Jianxiong. Majored in applied chemistry, I graduated from East China University of Science and Technology in 2023. It’s my honor to be a member of Tang Lab.

Runtao Zhao(赵润涛)

E-Mail: zrt2002@pku.edu.cn
WeChat: mauphu
Github: https://github.com/zrt2002
Hi, I am Zhao Runtao, graduated from Peking University and currently working on my PhD at Tanglab.

Wentao Chai(柴文涛)

My name is Chai Wentao, an undergraduate student from Peking University.I join Tang Lab in 2022 and do my undergraduate research about liquid-liquid phase separation.It’s my honor to be a member of Tang Lab.

Shangxiang Ye(叶尚祥)

Email: yeshangxiang@wipm.ac.cn

Hi, I am Shangxiang Ye. I obtained my Bachelor degree from Central China Normal University Now I am studying for a PhD in Tang lab. It’s my pleasure to be a member of Tang lab. And my main research work is to study the molecular mechanism of PINK1/Parkin-mediated mitophagy.

Chen Jingru (陈镜如)

E-mail: chenjingru@pku.edu.cn

Hi, I’m Chen Jingru, I completed my undergraduate study in physics at Central China Normal University, and now I am studying for a PhD at Peking University. Tanglab is a laboratory full of passion, creativity and love, I’m going to be a hot-wired, heat-seeking person, riding the wave, pushing the envelope in a sea of interdisciplinary subjects. I will make every effort to perform my duty, make my own contribution, and grow with Tanglab family side by side.

5月7—8日，以“强体魄，庆百年”为主题的北京大学第28届体育文化节暨2021年田径运动会在五四体育中心举行，全校万余名师生参加了本届运动会，运动会主要分为传统田径项目和趣味运动项目两部分。

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Lanthanoid tagging via an unnatural amino acid for protein structure characterization

Lanthanoid pseudo-contact shift (PCS) provides long-range structural information between a paramagnetic tag and protein nuclei. Here we report two lanthanoid probes, DTTA-C3-yne and DTTA-C4-yne, which can be conjugated to an unnatural amino acid pAzF in the target protein via azide-alkyne cycloaddition. The DTTA-based lanthanoid tags are associated with large magnetic susceptibility tensors owing to the rigidity of the tags.

Reference: J Biomol NMR, 2017, 67:273-282.

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Conjoined use of EM and NMR in RNA structure refinement

Hence structural characterization of large RNAs can be difficult for NMR alone. Electron microscopy (EM) provides global shape information of macromolecules at nanometer resolution, which should be complementary to NMR for RNA structure determination.

Reference: Plos One, 2015,10, e0120445.

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Integration of smFRET and NMR to study the dynamic structure and function of K48-linked ubiquitin chain

K48 linked ubiquitin chains can mediate the degradation of substrate protein by Proteasome. This study uses NMR as the main method to analyze the solution structure of K48-diUb:Rpn13NTD, In addition, using smFRET we proved that Rpn13 specifically binds to the closed state of the K48 linked ubiquitin chains through conformational selection. This work provides the structural baisis for Rpn13 linkage selectivity, which opens a new window for modulating proteasomal function.

Reference: Cell Discov, 2019, 5:9.

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CXMS

Chemical cross-linking coupled with mass spectroscopy (CXMS) provides proximity information for the cross-linked residues. Protein dynamics can be manifested from cross-links, as illustrated here with the open-closed domain movement for a two-domain protein.

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